Ang-(1–7) protects skeletal muscle function in aged mice

Abstract Background The angiotensin-converting enzyme 2 (ACE2)/angiotensin 1–7 (Ang-(1–7)) axis has been shown to protect against the age-associated decline in skeletal muscle function. Here, we investigated protective effects of ACE2 mitigating function and identify potential underlying molecular mechanisms. Methods We measured expression levels Ang-(1–7) C57BL/6J mice different ages correlated these with measures also myocyte enhancer factor A (MEF2A) knockout (ACE2KO) its relationship then treated aged ACE2KO for four weeks characterized MEF2A before after treatment. assessed impact on growth differentiation C2C12 cells vitro changes glucose transporter type 4 (Glut4). Results Aged showed reduced comparison young middle-aged mice. In mice, protein were significantly lower than age-matched wild-type (WT) After one month treatment, improved, while was similar that untreated group. cells, promote along upregulated Glut4. Conclusions ACE2/ a administration exogenous can delay age-related muscle.